The Millers were knocked out of the FA Cup at Leeds on Saturday and they return to a battle which sees them out of the Championship bottom three on goal difference.
Here are five things to look out for in the game.
Can Rotherham stop the team-talk changers?
Rotherham have been undermined by an inability to close out first halves this season as their FA Cup defeat at Leeds on Saturday was the eighth time they have conceded between the minutes 40-45. All of them have proved pivotal game-changers and left Neil Redfearn (and Steve Evans before him) ripping up his half-time team-talks. The Millers have to become better at game management and be able to see out periods when they are under the cosh if there is an end in sight.
What sort of condition will the Millers be in
The last thing the Millers could do with is a midweek fixture with their squad the way it is at the minute. Redfearn has depleted options at his disposal given injuries, loan recalls, and ineligibilities. The manager's game management at Elland Road suggested there was more than one eye on this clash, but even then they did not come through unscathed. Shay Facey was taken off at half-time feeling a tight hamstring while Danny Ward is now a doubt after aggravating a hip problem.
Continuing Brighton's goalscoring drought
Whisper it, but this could be a good time to play Brighton. For probably one of the first times this season Rotherham are coming up against a side who are not in their prime or on a roll. The early-season pacesetters, who were not beaten in the league until December, are having a decided wobble and are winless in eight games. They have not scored in five and they are making a second trip to Yorkshire in the space of three days. Of course, the ability to fly home from Hull on Saturday is wholly different from travelling by coach, but it will still be a lengthy journey and a night in a hotel. With the Seagulls struggling in front of goal and their tendency for a stalemate on the road - their nine is a divisional high - this could be the evening where Rotherham finally manage a draw!
Home comforts
However, recent form at New York Stadium suggests the Millers should be targeting three points. Three wins from their last four games on home soil has been encouraging and the performances against Hull and Bolton were enough to haul themselves out of the bottom three. The manner of those displays also give hope that they have got enough in front of their own fans to be able to sustain their fight against the drop. Redfearn's men have had three games on the road and they will be looking forward to some home comforts.
Tuesday night blues
The fact they are playing on a Tuesday might just unsettle them, though. It was too long ago that the Millers were pretty much invincible in midweek evening matches, losing just a couple of the back-to-back promotion seasons. However, their midweek form has been just another addition to the long list of struggles in the Championship. Since their return to the second tier 18 months ago, Rotherham have won just three games on a Tuesday night, drawn four, but lost 10. The positives there are that all three wins have been at New York while two Tuesday nights under the lights this season have ended in draws.
