The Millers doubled their points tally in Saturday's 1-1 draw and will be keen to build on that.
Here are five things to look out for
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Can the Millers build on their 'new start'?
Millers boss Steve Evans said that his side's season started at Charlton and it's fair to say it went a lot better than the actual start to the campaign, which was frankly traumatic. Now the Millers have to build on that promising performance at the Valley and try and create some momentum. They should have fresh energy and impetus from the three loan arrivals and an imposing presence in the net while the confidence levels will definitely be on the up after the weekend. Getting anything at the Amex will be no mean feat given Brighton's electric start to the season, but Evans' men are in a better position than 10 days ago to upset the odds.
Has Evans found his favoured back four?
A bonding exercise
The fixture list has not been the kindest to the Millers with Saturday's trip to the capital followed by their longest journey of the season three days later. To avoid racking up hours on the coach, the Millers have stayed in the south, training in Crawley - an area Evans and Paul Raynor know well. That will undoubtedly keep them fresh and means there can be no excuses when it comes to kick-off at the Amex. Also the mini-break will also provide crucial bonding time for the squad, who are still getting to know each other. The hope is that will help garner a spirit that has undoubtedly been missing in the early part of the term and that might have to be on show as they try and get something out of arguably their toughest game of the season to date.
Coping on the big stage
One of Rotherham's biggest weaknesses last season was that they were often sitting ducks when visiting the big teams and never looked capable of getting a result. Indeed, they only took four points from games at clubs who finished in the top half of the table, through draws at Bournemouth, Norwich, Cardiff and Charlton. It hasn't started too favourably so far this time around either, with defeats at QPR and Nottingham Forest, before another promising draw at Charlton. The trip to Brighton represents another test at a side doing well and how they fare will see what progress the Millers have made since the international break. Their chances in these types of games both last season and this have been the undermined by conceding goals at crucial times, or in quick succession, so keeping it tight will be key while, of course, sticking away any chances that come their way. Not easy against a side who have swept aside all that has come before them this season.