There wasn't much for the Millers to cheer about as they ended the first Saturday propping up the rest of the division.
Here is a numerical analysis of the game.
-3 - The number the Millers' goal difference currently stands on after a heavy loss.
0 - The number of times the Millers have beaten MK Dons in nine meetings.
2 - The number of changes boss Steve Evans made at half-time in a bid to turn round a 3-1 first-half deficit, with Grant Ward and Aidy White making way.
3 - The number of players in the Millers' starting line-up that were in the XI for the last game of last season at Leeds.
4 - The number of games since the Millers' last defeat at the New York Stadium.
4 - The number of goals the Millers conceded, the first time in 15 Championship games they have conceded more than three.
5 - The number of shots Matt Derbyshire had on goal against the Dons, of which only one yielded a goal.
7 - The number of defeats Rotherham have suffered against the Dons in just nine meetings.
8 - The number of debutants Evans fielded in his starting XI.
9 - The number of goals the Dons have scored against the Millers in their last three meetings.
9 - The number of crosses left-back Joe Newell put in throughout the 90 minutes.
11 - The number of regular left-backs Steve Evans has selected in three seasons and one game at the Millers helm following Newell's place in the starting XI, with one yet to play.
13 - The number of minutes it took Derbyshire to open his league account for the season, compared to the 16 games it took last year.
15 - The number of shots the Millers rained in on the Dons' net, throughout the 90 minutes, yielding only one goal.
21 - The number of years since the Millers were last beaten by a heavier scoreline on the opening day of the season - a 4-0 loss to Shrewsbury in 1994.
56 - The number of touches that Richie Smallwood had, which was the most of any Miller, compared to 93 by Dons defender Antony Kay.